MoBrain Competence Centre MoBrain Competence Centre

Today’s translational research era calls for innovative solutions to enable researchers and clinicians to build bridges between the microscopic (molecular) and macroscopic (human) scales. This requires building both transversal and vertical connections between techniques, researchers and clinicians to provide them with an optimal e-Science toolbox to tackle societal challenges related to health.

The main objective of the MoBrain Competence Center (CC) is to lower barriers for scientists to access modern e-Science solutions from micro to macro scales. MoBrain builds on grid- and cloud-based infrastructures and on the existing expertise available within WeNMR (www.wenmr.eu), N4U (neugrid4you.eu), and technology providers (NGIs and other institutions, OSG). This initiative aims to serve its user communities, related ESFRI projects (e.g. INSTRUCT) and in the long term the Human Brain Project (FET Flagship), and strengthen the EGI services offering.

By integrating molecular structural biology and medical imaging services and data, MoBrain will kick-start the development of a larger, integrated, global science virtual research environment for life and brain scientists worldwide. The mini-projects defined in MoBrain are geared toward facilitating this overall objective, each with specific objectives to reinforce existing services, develop new solutions and pave the path to global competence center and virtual research environment for translational research from molecular to brain.

There are already many services and support/training mechanisms in place that will be further developed, optimized and merged during the operation of the CC, building onto and contributing to the EGI service offering. MoBrain will produce a working environment that will be better tailored to the end user needs than any of its individual components. It will provide an extended portfolio of tools and data in a user-friendly e-laboratory, with a direct relevance for neuroscience, starting from the quantification of the molecular forces, protein folding, biomolecular interactions, drug design and treatments, improved diagnostic and the full characterization of every pathological mechanism of brain diseases through both phenomenological as well as mechanistic approaches.

 

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INSTRUCT practical course

Mobrain is co-organising an INSTRUCT practical course on advanced methods for the integration of diverse structural data with NMR data - Utrecht, April 11-15, 2016.

The course aims at training young researchers in the combined use of NMR data with other structural biology techniques, such as SAXS, X-ray diffraction or Cryo-EM in order to understand and rationalize the structural and dynamical properties of macromolecular systems. In addition, this course will introduce and make extensive use of user-friendly e-science portals to facilitate the adoption of the methods and techniques by the students in their everyday work.

This INSTRUCT course will provide lectures describing the basics of the methods applied and hands-on training with the intuitive, web-based services of the WeNMR infrastructure, in collaboration with the MoBrain Competence Center, the West-Life VRE and the BioExcel center of excellence H2020 EU projects, with the support of SURFSara, which is part of the MoBrain CC and is supporting us in the organisation of this course. The hands-on sessions will allow the students to try the methods on either pre-packaged or their own research data. The course will address state-of-the-art tools and facilities. Participants will be selected among all applicants taking into account the following criteria: previous experience in the field of biomolecular NMR and structure biology; experience in computational aspects of structural biology; gender balance; relevance of current research to the course contents.

Registration is open! Only two weeks left (and even if you are NMR group member, you will need to register since space is limited)

For details visit: http://www.bonvinlab.org/education/INSTRUCT-practical-course/